Thionyl Chloride → 1-(4-Fluorophenyl)-4-methoxy-pyrazole-3-carbonyl chloride

HRID 1465190노트

반응식

HRID 1465190 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([O:13][CH3:14])[C:10]([C:15]([OH:17])=O)=[N:9]2)=[CH:4][CH:3]=1.S(Cl)([Cl:20])=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([O:13][CH3:14])[C:10]([C:15]([Cl:20])=[O:17])=[N:9]2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 336766731-(4-fluorophenyl)-4-methoxy-1H-pyrazole-3-carboxylic acid

생성물 1

HCID 867081591-(4-Fluorophenyl)-4-methoxy-pyrazole-3-carbonyl chloride

실험 절차

E2 (100 mg, 0.42 mmol, 1.0 eq.) was heated in thionyl chloride (1 mL) for 4 h under reflux. Solvent was removed in vacuo and the crude material was resolved in dry toluene and evaporated under reduced pressure again to yield E3. The crude material was used in the next step without further purification.

후처리

  1. temperatureunder reflux
  2. customSolvent was removed in vacuo
  3. customevaporated under reduced pressure again

출처 및 근거

ORD 기록
ord-2fa6be84054c46c6b1d9512238ebc798
출처 데이터셋
uspto-grants-2015_04
특허 번호
US08999982B2

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