反应详情

E2 (100 mg, 0.42 mmol, 1.0 eq.) was heated in thionyl chloride (1 mL) for 4 h under reflux. Solvent was removed in vacuo and the crude material was resolved in dry toluene and evaporated under reduced pressure again to yield E3. The crude material was used in the next step without further purification.

1. temperatureunder reflux
2. customSolvent was removed in vacuo
3. customevaporated under reduced pressure again