HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-(4-Fluorophenyl)-4-methoxy-pyrazole-3-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(4-fluorophenyl)-4-methoxy-1H-pyrazole-3-carboxylic acid | HCID 33676673 | — |
| Product | 1-(4-Fluorophenyl)-4-methoxy-pyrazole-3-carbonyl chloride | HCID 86708159 | — |
Reaction Steps
E2 (100 mg, 0.42 mmol, 1.0 eq.) was heated in thionyl chloride (1 mL) for 4 h under reflux. Solvent was removed in vacuo and the crude material was resolved in dry toluene and evaporated under reduced pressure again to yield E3. The crude material was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08999982B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-2fa6be84054c46c6b1d9512238ebc798 |
| Source note | uspto-grants-2015_04 |