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HRID14652

反应详情

EQUATION

反应方程式

HRID 14652 的结构方程式

REACTANTS

反应物

2
结构：[Li+].[OH-]
HCID3939

Lithium hydroxide anhydrous

HLiO

结构：CCOC(=O)c1cnc(CNC(=O)OC(C)(C)C)c2cc(OC)c(OC)cc12
HCID59341107

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc2c(C(=O)O)cnc(CNC(=O)OC(C)(C)C)c2cc1OC
HCID59341071

未命名化合物

PROCEDURE

实验过程

A sample of 1-(tert-butoxycarbonylamino-methyl)-6,7-dimethoxy-isoquinoline-4-carboxylic acid ethyl ester was hydrolyzed with 2 eq of LiOH as described in Example 1D to give 1-(tert-Butoxycarbonylamino-methyl)-6,7-dimethoxy-isoquinoline-4-carboxylic acid: 1H NMR (DMSO-d6) δ 1.37 (s, 9H), 3.90 (s, 3H), 3.93 (s, 3H), 4.74 (d, 2H), 7.33-7.36 (m, 1H), 7.61 (s, 1H), 8.37 (s, 1H), 8.82 (s, 1H).