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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1465200Generated: October 26, 2026

1,5-Dimethyl-1H-Pyrazole-3-Carbonyl Chloride → N-[3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]phenyl]-1,5-dimethyl-pyrazole-3-carboxamide

https://huagongshe.com/reaction/1465200

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,5-Dimethyl-1H-Pyrazole-3-Carbonyl ChlorideHCID 2776364—
Reactant3-Fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)anilineHCID 46928040—
ProductN-[3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]phenyl]-1,5-dimethyl-pyrazole-3-carboxamideHCID 56846800—

Reaction Steps

Q5 was prepared from 3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]aniline and 1,5-dimethyl-1H-pyrazole-3-carbonyl chloride following the general procedure reported in Preparative Example 1 Step 3. MS (ES) C29H32FN5O5 requires: 549. Found: 550 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08999982B2
Source datasetuspto-grants-2015_04
ORD IDord-0333246740124ccc95786828def1581a
Source noteuspto-grants-2015_04