2-Methyl-5-vinylpyridine → HCID 57876007, compound

HRID 1465288Notes

Reaction equation

HRID 1465288 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:22][CH2:21][C:12]3[NH:13][C:14]4[CH:15]=[CH:16][C:17]([CH3:20])=[CH:18][C:19]=4[C:11]=3[CH2:10]2)=[CH:5][CH:4]=1.[CH3:23][C:24]1[CH:29]=[CH:28][C:27]([CH:30]=[CH2:31])=[CH:26][N:25]=1.[OH-].[K+]>CN1C(=O)CCC1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:22][CH2:21][C:12]3[N:13]([CH2:31][CH2:30][C:27]4[CH:26]=[N:25][C:24]([CH3:23])=[CH:29][CH:28]=4)[C:14]4[CH:15]=[CH:16][C:17]([CH3:20])=[CH:18][C:19]=4[C:11]=3[CH2:10]2)=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 88172-Methyl-5-vinylpyridineHCID 14797Potassium HydroxideHCID 68925905HCID 68925905, compound

Product 1

HCID 57876007HCID 57876007, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The title compound is prepared from a mixture of 2,3,4,5-tetrahydro-2(4-methoxyphenyl)-8-methyl-1H-pyrido[4,3-b]indole, 2-methyl-5-vinylpyridine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Workup

  1. customranging between 25 deg C
  2. customto 100 deg C
  3. customThe product obtained
  4. customis isolated by preparative HPLC

Sources & evidence

ORD record
ord-630b2b9434ea4a3eb26a4a123b63356a
Source dataset
uspto-grants-2015_04
Patent number
US08999978B2

Reaction notes

Loading…