1,4-Dioxane hydrochloride → HCID 67030367, compound

Participants

Reaction Steps

tert-Butyl{2-[(4-bromophenyl)(ethyl)amino]ethyl}carbamate (896 mg) synthesized in Production Example 83, step 3 was dissolved in dioxane (5 ml), and 4M-hydrogen chloride dioxane solution (5 ml, 20 mmol) was added dropwise at 0° C. After stirring at room temperature for 2 hrs, the mixture was concentrated under reduced pressure. Dichloromethane was added to the residue, and the mixture was concentrated under reduced pressure, which operation was performed 3 times to remove volatile components such as hydrogen chloride and the like. The residue was dried under reduced pressure to give N-(4-bromophenyl)-N-ethylethane-1,2-diamine dihydrochloride (1.044 g) as a yellow gum-like solid.

Provenance & Evidence