tert-Butyl piperazine-1-carboxylate → HCID 58181279, compound

HRID 1465466Notes

Reaction equation

HRID 1465466 reaction equation
[Cl:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[N:13]1([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:16]2[CH2:15][CH2:14][N:13]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:18][CH2:17]2)[CH:5]=[CH:6][C:7]=1[C:8]([F:11])([F:10])[F:9]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 18103372,6-Dichloro-3-(trifluoromethyl)pyridine

Product 1

HCID 58181279HCID 58181279, compoundYield 65.2%

Procedure

tert-Butyl 4-[6-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxylate (1.67 g, yield 65%, off-white solid) was synthesized from 2,6-dichloro-3-(trifluoromethyl)pyridine (1.51 g, 7.0 mmol) and tert-butyl piperazine-1-carboxylate (1.56 g, 8.38 mmol) by a method similar to Production Example 96, step 2.

Sources & evidence

ORD record
ord-730aa208996f4effb95b181ef5f5c68f
Source dataset
uspto-grants-2015_04
Patent number
US08999989B2

Reaction notes

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