HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl piperazine-1-carboxylate → HCID 58181279, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 2,6-Dichloro-3-(trifluoromethyl)pyridine | HCID 1810337 | — |
| Product | HCID 58181279 | HCID 58181279 | 65.2% |
Reaction Steps
tert-Butyl 4-[6-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxylate (1.67 g, yield 65%, off-white solid) was synthesized from 2,6-dichloro-3-(trifluoromethyl)pyridine (1.51 g, 7.0 mmol) and tert-butyl piperazine-1-carboxylate (1.56 g, 8.38 mmol) by a method similar to Production Example 96, step 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08999989B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-730aa208996f4effb95b181ef5f5c68f |
| Source note | uspto-grants-2015_04 |