HCID 86651849, compound → HCID 67030757, compound

HRID 1465497Notes

Reaction equation

HRID 1465497 reaction equation
[Br-].[C:2](/[CH:5]=[CH:6]/[C:7]1[CH:32]=[CH:31][C:10]([CH2:11][P+](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=[CH:9][CH:8]=1)([OH:4])=[O:3].[C:33]([C:36]1[CH:41]=[CH:40][N:39]([C:42]2[CH:43]=[CH:44][C:45]([CH:48]=O)=[N:46][CH:47]=2)[CH2:38][CH:37]=1)(=[O:35])[CH3:34]>>[C:33]([C:36]1[CH:37]=[CH:38][N:39]([C:42]2[CH:43]=[CH:44][C:45]([CH:48]=[CH:11][C:10]3[CH:9]=[CH:8][C:7](/[CH:6]=[CH:5]/[C:2]([OH:4])=[O:3])=[CH:32][CH:31]=3)=[N:46][CH:47]=2)[CH2:40][CH:41]=1)(=[O:35])[CH3:34]

Participants

3

Reactant 2

HCID 86651849HCID 86651849, compoundHCID 86651851HCID 86651851, compound

Product 1

HCID 67030757HCID 67030757, compoundYield 95.3%

Procedure

Production Example 108, step 4, {4-[(E)-2-carboxyvinyl]benzyl}(triphenyl)phosphonium bromide (503.9 mg, 1.001 mmol) and 5-(4-acetylpyridin-1-yl)pyridine-2-carbaldehyde (257.3 g, 1.103 mmol) were condensed to give (2E)-3-(4-{2-[5-(4-acetylpyridin-1-yl)pyridin-2-yl]vinyl}phenyl)prop-2-enoic acid (355.1 mg, yield 94.0%) as a pale-brown solid.

Workup

  1. customcondensed

Sources & evidence

ORD record
ord-d37310d4092946ecb0fbdcb47d4925bd
Source dataset
uspto-grants-2015_04
Patent number
US08999989B2

Reaction notes

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