tert-Butyl carbazate → HCID 67030348, compound

HRID 1465498Notes

Reaction equation

HRID 1465498 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][N:7]([C:10]2[CH:11]=[CH:12][C:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][C:26](O)=[O:27])=[CH:20][CH:19]=3)=[N:14][CH:15]=2)[CH2:6][CH:5]=1)(=[O:3])[CH3:2].[C:29]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])(=[O:32])[NH:30][NH2:31]>>[C:1]([C:4]1[CH:5]=[CH:6][N:7]([C:10]2[CH:11]=[CH:12][C:13]([CH2:16][CH2:17][C:18]3[CH:19]=[CH:20][C:21]([CH2:24][CH2:25][C:26]([NH:31][NH:30][C:29]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])=[O:27])=[CH:22][CH:23]=3)=[N:14][CH:15]=2)[CH2:8][CH:9]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 70091tert-Butyl carbazateHCID 67031019HCID 67031019, compound

Product 1

HCID 67030348HCID 67030348, compoundYield 85%

Procedure

By a method similar to Production Example 118, step 3, 3-(4-{2-[5-(4-acetylpyridin-1-yl)pyridin-2-yl]ethyl}phenyl)propionic acid (267.2 mg, 0.700 mmol) and tert-butyl carbazate (559.9 mg, 4.237 mmol) were condensed to give tert-butyl 2-[3-(4-{2-[5-(4-acetylpyridin-1-yl)pyridin-2-yl]ethyl}phenyl)propanoyl]hydrazinecarboxylate (292.0 mg, yield 84.1%) as a white solid.

Workup

  1. customcondensed

Sources & evidence

ORD record
ord-960345bb97f6429786d6cbae47f1b000
Source dataset
uspto-grants-2015_04
Patent number
US08999989B2

Reaction notes

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