反应详情

温度

37.5 °C

To methyl (2E)-3-[4-(1,3-dioxolan-2-yl)thiophen-2-yl]prop-2-enoate (2.200 g, 9.156 mmol) was added 50% acetic acid aqueous solution (22 ml), and the mixture was stirred at 35 to 40° C. for 2 hrs. The reaction mixture was concentrated under reduced pressure, and water (50 ml) was added. The mixture was concentrated again under reduced pressure, and water (100 ml) was added. The precipitate was collected by filtration, washed with water, and dried under reduced pressure to give methyl (2E)-3-(4-formylthiophen-2-yl)prop-2-enoate (1.701 g, yield 94.7%) as a white solid.

1. concentrationThe reaction mixture was concentrated under reduced pressure, and water (50 ml)
2. additionwas added
3. concentrationThe mixture was concentrated again under reduced pressure, and water (100 ml)
4. additionwas added
5. filtrationThe precipitate was collected by filtration
6. washwashed with water
7. customdried under reduced pressure