methyl (2E)-3-[4-(1,3-dioxolan-2-yl)thiophen-2-yl]acrylate → methyl (2E)-3-(4-formylthiophen-2-yl)acrylate

Participants

Reaction Conditions

Reaction Steps

To methyl (2E)-3-[4-(1,3-dioxolan-2-yl)thiophen-2-yl]prop-2-enoate (2.200 g, 9.156 mmol) was added 50% acetic acid aqueous solution (22 ml), and the mixture was stirred at 35 to 40° C. for 2 hrs. The reaction mixture was concentrated under reduced pressure, and water (50 ml) was added. The mixture was concentrated again under reduced pressure, and water (100 ml) was added. The precipitate was collected by filtration, washed with water, and dried under reduced pressure to give methyl (2E)-3-(4-formylthiophen-2-yl)prop-2-enoate (1.701 g, yield 94.7%) as a white solid.

Provenance & Evidence