Hydrochloric Acid → HCID 178468222, compound

HRID 1465696Notes

Reaction equation

HRID 1465696 reaction equation
[ClH:1].[Br:2][C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]#[N:13])[CH:10]=2)[NH:5][N:4]=1.N1C2C(=CC=CC=2)C=N1.[CH3:23][CH2:24][OH:25]>CCOCC>[ClH:1].[Br:2][C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12](=[NH:13])[O:25][CH2:24][CH3:23])[CH:10]=2)[NH:5][N:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 178509532HCID 178509532, compound

Product 1

HCID 178468222HCID 178468222, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Passed HCl (g) slowly into a suspension of indazole 3-bromo-1H-indazole-5-carbonitrile (7 g) in EtOH (USP, 300 ml) at 0° C. Stirred at 0° C.-5° C. for approximately 2 hours until precipitation occurred, and stirred overnight at room temperature. Diluted with Ether (ca. 300 ml) and filtered out white solid, dried at room temperature to yield ethyl 3-bromo-1H-indazole-5-carbimidate hydrochloride (7.5 g).

Workup

  1. stirringstirred overnight at room temperature
  2. filtrationfiltered out white solid
  3. customdried at room temperature

Sources & evidence

ORD record
ord-c5679c063cbe4b00a48cabb0b27fedd4
Source dataset
uspto-grants-2015_04
Patent number
US08999966B2

Reaction notes

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