反应详情

tert-Butyl 4-(6-cyanoquinolin-2-yl)-3-oxopiperazine-1-carboxylate (0.15 g, 0.79 mmol) was treated with TFA (2 mL) and stirred for 20 minutes. Analysis of the reaction mixture by LC indicated the reaction had gone to completion. The solution was concentrated in vacuo and crude was azetroped (3×) with dichloroethane to furnish the title product. LC/MS (IE, m/z): [M+1]+=253.

1. concentrationThe solution was concentrated in vacuo and crude