反应详情

温度

110 °C

A mixture of 7-Methyl-2-oxo-1,2-dihydroquinoline-6-carbonitrile (10 g, 54 mmol) and POCl3 (30 mL) was stirred at 110° C. for 2 h and then at 20° C. overnight. The mixture was carefully poured into a mixture of water and ice (400 mL) while being stirred vigorously. The product was collected by filtration and dried by co-evaporation with MeCN/Toluene to furnish the title product. LC/MS (IE, m/z): [M+1]+=203.

1. customat 20° C.
2. customovernight
3. stirringwhile being stirred vigorously
4. filtrationThe product was collected by filtration
5. dry with materialdried by co-evaporation with MeCN/Toluene