Trifluoroacetic acid → HCID 89525152, compound

HRID 1465740Notes

Reaction equation

HRID 1465740 reaction equation
[C:1]([C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([N:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][C:14]3=[O:26])[CH:9]=[N:10]2)=[CH:5][CH:4]=1)#[N:2].C(O)(C(F)(F)F)=O>>[O:26]=[C:14]1[CH2:15][NH:16][CH2:17][CH2:18][N:13]1[C:8]1[CH:9]=[N:10][C:11]2[C:6]([CH:7]=1)=[CH:5][CH:4]=[C:3]([C:1]#[N:2])[CH:12]=2

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131732664HCID 131732664, compound

Product 1

HCID 89525152HCID 89525152, compound

Procedure

tert-Butyl 4-(7-cyanoquinolin-3-yl)-3-oxopiperazine-1-carboxylate (0.030 g, 0.099 mmol) was treated with TFA (2 mL) and stirred for 20 minutes. Analysis of the reaction mixture by LC indicated that reaction had gone to completion. The solution was concentrated in vacuo and crude was azetroped with dichloroethane (3×8 mL) to furnish the title product. LC/MS (IE, m/z): [M+1]+=253.

Workup

  1. customAnalysis of the reaction mixture by LC indicated that reaction
  2. concentrationThe solution was concentrated in vacuo and crude

Sources & evidence

ORD record
ord-bdb65c0c4a6c45c3bfea573c18d43d16
Source dataset
uspto-grants-2015_04
Patent number
US08999991B2

Reaction notes

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