HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(2-Oxopiperazin-1-yl)isoquinoline-7-carbonitrile hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(7-cyanoisoquinolin-3-yl)-3-oxopiperazine-1-carboxylate | HCID 89525285 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-(2-Oxopiperazin-1-yl)isoquinoline-7-carbonitrile hydrochloride | HCID 89525109 | — |
Reaction Steps
The product of Step B was further treated with 4N HCl in dioxane, and removal of solvent furnished 3-(2-oxopiperazin-1-yl)isoquinoline-7-carbonitrile hydrochloride. The HCl salt was washed with aqueous sodium carbonate, and back extracted with CHCl3-IPA (3:1) to furnish the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08999991B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-11fd0351b9cd4a05be8a5f8fee0e2a54 |
| Source note | uspto-grants-2015_04 |