反应详情

To a flask charged with 6-Chlorothieno[2,3-b]pyridine (500 mg, 3.0 mmol) and a stir bar was added NIS (800 mg, 3.5 mmol) and Triflic acid (5 mL). The mixture was monitored by TLC and allowed to stir at RT for 4 hours. The reaction was poured into ice, neutralized with aqueous sodium carbonate, extracted with DCM, dried over sodium sulfate, concentrated and purified by flash chromatography (Hex: EtOAc gradient) to obtain the title product. LC-MS (IE, m/z): 296 [M+1]+.

1. additionThe reaction was poured into ice
2. extractionextracted with DCM
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated
5. custompurified by flash chromatography (Hex: EtOAc gradient)