HRID1465792
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 120 °C
PROCEDURE
实验过程
A mixture of 4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-2-one [I-10] (30 mg, 0.10 mmol), 2-chloro-1,3-benzothiazole-6-carbonitrile (20 mg, 0.10 mmol), Pd2(dba)3 (19 mg, 0.021 mmol), Xantphos (24 mg, 0.041 mmol), and Cs2CO3 (50 mg, 0.16 mmol) in dioxane (2 mL) was sealed in a microwave tube and purged three times with nitrogen. It was heated to 120° C. for 10 minutes in a microwave reactor. LC showed formation of the title product, which was purified by silica gel flash chromatography. LC-MS (IE, m/z): 449 [M+1]+.
WORKUP
后处理
- customwas sealed in a microwave tube
- custompurged three times with nitrogen
- customwas purified by silica gel flash chromatography