反应详情

To a solution of methyl 4-acetamido-2-methoxy-5-nitrobenzoate (135 mg, 0.50 mmol) in ethanol 10 ml) was added concentrated hydrochloric acid (0.5 ml) dropwise and the mixture refluxed under nitrogen overnight. The reaction mixture was then cooled, the solvents removed and the residue purified by column chromatography (silica gel), eluting with 1:1 ethyl acetate/hexane to give ethyl 4-amino-2-methoxy-5-nitrobenzoate as a yellow solid (110 mg, 91%).

1. temperaturethe mixture refluxed under nitrogen overnight
2. temperatureThe reaction mixture was then cooled
3. customthe solvents removed
4. customthe residue purified by column chromatography (silica gel)
5. washeluting with 1:1 ethyl acetate/hexane