Phosphorus oxychloride → HCID 178480563, 화합물

HRID 1465981노트

반응식

HRID 1465981 반응식
[CH3:1][N:2]1[C:7](=[O:8])[C:6]2[C:9]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[N:10][NH:11][C:5]=2[NH:4][C:3]1=O.O=P(Cl)(Cl)[Cl:22]>>[Cl:22][C:3]1[N:2]([CH3:1])[C:7](=[O:8])[C:6]2[C:9]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[N:10][NH:11][C:5]=2[N:4]=1

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 178481638HCID 178481638, 화합물

생성물 1

HCID 178480563HCID 178480563, 화합물수율 47%

실험 절차

5-methyl-3-(phenylamino)-1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (450 mg, 1.75 mmol) is refluxed in POCl3 (20 mL) for 60 hours, and the mixture is evaporated to dryness. The residue is purified by silica gel flash chromatography to give 122 mg product as white solids and 207 mg starting material is recovered (Yield: 47%). MS (FAB) m/z 276.1 [M+H]+.

후처리

  1. customthe mixture is evaporated to dryness
  2. customThe residue is purified by silica gel flash chromatography

출처 및 근거

ORD 기록
ord-338b948e8caf496181b49200bef090a3
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09000001B2

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