Hydrochloric Acid → 6-(2-Oxopiperazin-1-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

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Reaction Steps

To a flask charged with tert-Butyl 4-(6-cyano-1,2,3,4-tetrahydronaphthalen-2-yl)-3-oxopiperazine-1-carboxylate (450 mg, 1.3 mmol) was added 4N HCl in dioxane. The mixture was allowed to stir at RT for 1 hour. LC showed complete reaction. The volatiles were removed under reduced pressure, and the resulting solids were used without further purification. LC-MS (IE, m/z): 256 [M+1]+.

Provenance & Evidence