反应详情

To a flask was added tert-Butyl 6-methoxy-2-methyl3-[{2-oxopiperazin-1-yl}acetyl]benzonitrile (0.060 g, 0.15 mmol) followed by addition of TFA (2 mL) and a stir bar; the resulting mixture was stirred for 20 minutes. Analysis of the reaction mixture by LC indicated that reaction had gone to completion. The solution was concentrated in vacuo and the crude was co-evaporated with dichloroethane (3×8 mL) to furnish the title product. LC/MS (IE, m/z): [M+1]+=288.

1. customAnalysis of the reaction mixture by LC indicated that reaction
2. concentrationThe solution was concentrated in vacuo