反应详情

温度

140 °C

To a flask charged with Ethyl N-(2-{(tert-butoxycarbonyl)[(4-cyano-5-fluoro-2,3-dihydro-1H-inden-1-yl)methyl]amino}ethyl)glycinate (30 mg, 0.072 mmol) was treated with HCl (1.78 ml, 7.2 mmol) to removed the BOC group. The solvent was removed when the deprotection was done. The residue was dissolved in EtOH (10 ml). To this solution was added a few drops of Hunig base. The solution was sealed in a microwave tube and heated to 140° C. for 30 minutes. The resulting title product was purified by MPLC. LC-MS (IE, m/z): 274 [M+1]+.

1. customto removed the BOC group
2. customThe solvent was removed when the deprotection
3. dissolutionThe residue was dissolved in EtOH (10 ml)
4. additionTo this solution was added a few drops of Hunig base
5. customThe solution was sealed in a microwave tube
6. customThe resulting title product was purified by MPLC