Methyl 2-nitro-5-(2-oxoethyl)benzoate → Methyl 2-nitro-5-(2-{4-[2-(4-nitrophenyl)ethyl]-3-oxopiperazin-1-yl}ethyl)benzoate

HRID 1466125Notes

Reaction equation

HRID 1466125 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][NH:15][CH2:14][C:13]2=[O:18])=[CH:6][CH:5]=1)([O-:3])=[O:2].[N+:19]([C:22]1[CH:31]=[CH:30][C:29]([CH2:32][CH:33]=O)=[CH:28][C:23]=1[C:24]([O:26][CH3:27])=[O:25])([O-:21])=[O:20]>>[N+:19]([C:22]1[CH:31]=[CH:30][C:29]([CH2:32][CH2:33][N:15]2[CH2:16][CH2:17][N:12]([CH2:11][CH2:10][C:7]3[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=3)[C:13](=[O:18])[CH2:14]2)=[CH:28][C:23]=1[C:24]([O:26][CH3:27])=[O:25])([O-:21])=[O:20]

Participants

3

Reactant 2

HCID 89524855Methyl 2-nitro-5-(2-oxoethyl)benzoateHCID 895248911-[2-(4-Nitrophenyl)ethyl]piperazin-2-one

Product 1

HCID 89533512Methyl 2-nitro-5-(2-{4-[2-(4-nitrophenyl)ethyl]-3-oxopiperazin-1-yl}ethyl)benzoate

Procedure

The title compound was prepared from 1-[2-(4-Nitrophenyl)ethyl]piperazin-2-one and Methyl 2-nitro-5-(2-oxoethyl)benzoate following essentially the same procedure as Example 6. The product was purified by mass-directed reverse phase HPLC (AcCN-Water with 0.1% TFA). LC-MS (IE, m/z): 457 [M+1]+.

Workup

  1. customThe product was purified by mass-directed reverse phase HPLC (AcCN-Water with 0.1% TFA)

Sources & evidence

ORD record
ord-acf3bc05a9704b6c816690b1c90a4687
Source dataset
uspto-grants-2015_04
Patent number
US08999990B2

Reaction notes

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