Dimethyl Sulfoxide → 4-Boc-1-(5-bromo-2-pyridyl)piperazine

HRID 146613Notes

Reaction equation

HRID 146613 reaction equation
[Br:14][c:15]1[n:16][cH:17][c:18]([Br:21])[cH:19][cH:20]1.[C:22](=[O:23])([O-:24])[O-:25].[CH3:28][S:29](=[O:30])[CH3:31].[CH3:32][CH2:33][O:34][C:35](=[O:36])[CH3:37].[K+:26].[K+:27].[N:1]1([C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:2][CH2:3][NH:4][CH2:5][CH2:6]1>>[N:1]1([C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:2][CH2:3][N:4]([c:15]2[n:16][cH:17][c:18]([Br:21])[cH:19][cH:20]2)[CH2:5][CH2:6]1

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 693532,5-DibromopyridineHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 112447754-Boc-1-(5-bromo-2-pyridyl)piperazine

Sources & evidence

ORD record
ord-0f183b82f7b74a4f98a66a4f8400a063
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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