反应详情

To a solution of product from Step C (0.39 mmol) in 20 mL of DCM/MeOH (3/1, v/v) was added HOAc (47 mg, 0.78 mmol), (1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetaldehyde (68 mg, 0.39 mmol) and NaBH3CN (49 mg, 0.78 mmol), and the mixture was stirred at RT for 2 hours. The reaction was diluted with DCM, washed with brine. The organic layer was dried over anhydrous Na2SO4 and concentrated. The residue was purified by prep-TLC to give the title product.

1. washwashed with brine
2. dry with materialThe organic layer was dried over anhydrous Na2SO4
3. concentrationconcentrated
4. customThe residue was purified by prep-TLC