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HRID1466178

反应详情

EQUATION

反应方程式

HRID 1466178 的结构方程式

REACTANTS

反应物

2
结构：Cc1c([C@H]2CO2)ccc2c1COC2=O
HCID59568665

4-Methyl-5-[(2S)-oxiran-2-yl]-2-benzofuran-1(3H)-one

C11H10O3

结构：Cc1c(CCN2CCNCC2=O)ccc2c1COC2=O
HCID89533477

未命名化合物

PRODUCTS

生成物

1
结构：Cc1c(CCN2CCN(C[C@@H](O)c3ccc4c(c3C)COC4=O)CC2=O)ccc2c1COC2=O
HCID117599515

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

CONDITIONS

反应条件

温度
100 °C

PROCEDURE

实验过程

A sealed tube containing 1-[2-(4-Methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-2-one (60 mg, 0.19 mmol) and 4-methyl-5-[(2S)-oxiran-2-yl]-2-benzofuran-1(3H)-one dissolved in 1 mL of EtOH was heated to 100° C. overnight. After 16 hrs the solvent was removed and the material purified via flash chromatography to give desired product. LC-MS (IE, m/z): 465 [M+1]+.

WORKUP

后处理

  1. customAfter 16 hrs the solvent was removed
  2. customthe material purified via flash chromatography