HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1466178Generated: October 31, 2026
(S)-4-methyl-5-(oxiran-2-yl)isobenzofuran-1(3H)-one → 4-[(2S)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-1-[2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-2-one
https://huagongshe.com/reaction/1466178
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (S)-4-methyl-5-(oxiran-2-yl)isobenzofuran-1(3H)-one | HCID 59568665 | — |
| Reactant | 1-[2-(1,3-Dihydro-4-methyl-1-oxo-5-isobenzofuranyl)ethyl]-2-piperazinone | HCID 89533477 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-[(2S)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-1-[2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-2-one | HCID 117599515 | — |
Reaction Steps
A sealed tube containing 1-[2-(4-Methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-2-one (60 mg, 0.19 mmol) and 4-methyl-5-[(2S)-oxiran-2-yl]-2-benzofuran-1(3H)-one dissolved in 1 mL of EtOH was heated to 100° C. overnight. After 16 hrs the solvent was removed and the material purified via flash chromatography to give desired product. LC-MS (IE, m/z): 465 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08999990B2 |
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| Source dataset | uspto-grants-2015_04 |
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| ORD ID | ord-6e24167c0b25476fad7496bb066b107a |
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| Source note | uspto-grants-2015_04 |
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