Acetonitrile → 3,5-dimethoxy-4-(4-methoxy-benzyloxy)-2-(1-methyl-1H-pyrazol-4-ylethynyl)pyridine

HRID 146621Notes

Reaction equation

HRID 146621 reaction equation
[C:22](#[CH:23])[c:24]1[cH:25][n:26][n:27]([CH3:29])[cH:28]1.[CH3:30][C:31]#[N:32].[Cu:33][I:34].[I:1][c:2]1[n:3][cH:4][c:5]([O:20][CH3:21])[c:6]([O:10][CH2:11][c:12]2[cH:13][cH:14][c:15]([O:18][CH3:19])[cH:16][cH:17]2)[c:7]1[O:8][CH3:9]>>[c:2]1([C:23]#[C:22][c:24]2[cH:25][n:26][n:27]([CH3:29])[cH:28]2)[n:3][cH:4][c:5]([O:20][CH3:21])[c:6]([O:10][CH2:11][c:12]2[cH:13][cH:14][c:15]([O:18][CH3:19])[cH:16][cH:17]2)[c:7]1[O:8][CH3:9]

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 511383214-Ethynyl-1-methyl-1H-pyrazoleHCID 592006432-Iodo-3,5-dimethoxy-4-(4-methoxy-benzyloxy)-pyridine

Product 1

HCID 686980513,5-dimethoxy-4-(4-methoxy-benzyloxy)-2-(1-methyl-1H-pyrazol-4-ylethynyl)pyridine

Sources & evidence

ORD record
ord-f354f63d1f194450905a46a488952d55
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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