Trifluoroacetic acid → HCID 71150054, compound

HRID 1466228Notes

Reaction equation

HRID 1466228 reaction equation
C([O:5][C:6]1[CH:11]=[C:10]([C:12]2[CH:34]=[CH:33][C:15]([CH2:16][NH:17][C:18](=[O:32])[C:19]3[C:24]([Cl:25])=[CH:23][C:22]([O:26][CH2:27][CH2:28][O:29][CH3:30])=[CH:21][C:20]=3[Cl:31])=[CH:14][CH:13]=2)[CH:9]=[CH:8][N:7]=1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[Cl:31][C:20]1[CH:21]=[C:22]([O:26][CH2:27][CH2:28][O:29][CH3:30])[CH:23]=[C:24]([Cl:25])[C:19]=1[C:18]([NH:17][CH2:16][C:15]1[CH:33]=[CH:34][C:12]([C:10]2[CH:9]=[CH:8][NH:7][C:6](=[O:5])[CH:11]=2)=[CH:13][CH:14]=1)=[O:32]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71149924HCID 71149924, compound

Product 1

HCID 71150054HCID 71150054, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound N-(4-(2-tert-butoxypyridin-4-yl)benzyl)-2,6-dichloro-4-(2-methoxy ethoxy)benzamide was re-dissolved in DCM (2 mL) and trifluoroacetic acid (2 mL) and stirred at room temperature for 1 h. after the reaction was done it was concentrated in vacuum and then purified by reverse phase chromatography to afford 2,6-dichloro-4-(2-methoxyethoxy)-N-(4-(2-oxo-1,2-dihydropyridin-4-yl)benzyl)benzamide.

Workup

  1. concentrationwas concentrated in vacuum
  2. custompurified by reverse phase chromatography

Sources & evidence

ORD record
ord-82f12e2f602344e1926da190b8c42ec7
Source dataset
uspto-grants-2015_04
Patent number
US09000015B2

Reaction notes

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