Trifluoroacetic acid → HCID 71150045, compound

HRID 1466233Notes

Reaction equation

HRID 1466233 reaction equation
C([O:5][C:6]1[CH:11]=[C:10]([C:12]2[CH:30]=[CH:29][C:15]([CH2:16][NH:17][C:18](=[O:28])[C:19]3[C:24]([F:25])=[CH:23][CH:22]=[C:21]([F:26])[C:20]=3[Cl:27])=[CH:14][CH:13]=2)[CH:9]=[CH:8][N:7]=1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[Cl:27][C:20]1[C:21]([F:26])=[CH:22][CH:23]=[C:24]([F:25])[C:19]=1[C:18]([NH:17][CH2:16][C:15]1[CH:29]=[CH:30][C:12]([C:10]2[CH:9]=[CH:8][NH:7][C:6](=[O:5])[CH:11]=2)=[CH:13][CH:14]=1)=[O:28]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71149959HCID 71149959, compound

Product 1

HCID 71150045HCID 71150045, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound N-(4-(2-tert-butoxypyridin-4-yl)benzyl)-2-chloro-3,6-difluorobenzamide was re-dissolved in DCM (2 mL) and trifluoroacetic acid (2 mL) and stirred at room temperature for 1 h. The reaction mixture was concentrated in vacuum and then purified by reverse phase chromatography to afford 2-chloro-3,6-difluoro-N-(4-(2-oxo-1,2-dihydropyridin-4-yl)benzyl)benzamide.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuum
  2. custompurified by reverse phase chromatography

Sources & evidence

ORD record
ord-47c358b479ef4016a663d272b8d215e3
Source dataset
uspto-grants-2015_04
Patent number
US09000015B2

Reaction notes

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