Hydrazine → Ethyl 3,5-diamino-1H-pyrazole-4-carboxylate
Reaction equation
[NH2:1][NH2:2].[NH2:3]/[C:4](/C(Cl)(Cl)Cl)=[C:5](/[C:11]#[N:12])\[C:6]([O:8][CH2:9][CH3:10])=[O:7]>CN(C=O)C>[NH2:3][C:4]1[C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[C:11]([NH2:12])[NH:2][N:1]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
Hydrazine (2.19 mL, 70 mmol) was added to (Z)-ethyl 3-amino-4,4,4-trichloro-2-cyanobut-2-enoate (15.0 g, 58 mmol) in DMF (50 mL). The reaction mixture was heated to 100° C. for 1 hr, then cooled to room temperature. The DMF was removed in vacuo, then the residue was slurried in a 95:5 mixture of DCM:2M methanolic ammonia solution. The resulting precipitate was filtered off, washed with a 95:5 mixture of DCM:MeOH, and dried under vacuum to afford 5.72 g (58%) of ethyl 3,5-diamino-1H-pyrazole-4-carboxylate as a white solid. 1H NMR (400 MHz, DMSO) δ 10.53 (s, 1H), 5.28 (br, 4H), 4.14 (q, J=7.1, 2H), 1.33-1.15 (t, J=7.1, 3H).
Workup
- temperaturecooled to room temperature
- customThe DMF was removed in vacuo
- additionthe residue was slurried in a 95:5 mixture of DCM
- filtrationThe resulting precipitate was filtered off
- washwashed with a 95:5 mixture of DCM
- dry with materialMeOH, and dried under vacuum
Sources & evidence
- ORD record
- ord-c160e69a528f4d48be912875943f487f
- Source dataset
- uspto-grants-2015_04
- Patent number
- US08999998B2
Reaction notes
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