Thionyl Chloride → 3-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride

HRID 1466647Notes

Reaction equation

HRID 1466647 reaction equation
[CH3:1][N:2]1[CH:6]=[N:5][C:4]([CH2:7]O)=[N:3]1.O=S(Cl)[Cl:11]>>[ClH:11].[Cl:11][CH2:7][C:4]1[N:5]=[CH:6][N:2]([CH3:1])[N:3]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 10351670(1-Methyl-1H-1,2,4-triazol-3-yl)methanol

Product 1

HCID 225069273-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride

Procedure

(1-methyl-1H-1,2,4-triazol-3-yl)methanol (0.25 g, 2.2 mmol) was dissolved in 10 mL of SOCl2 and refluxed for 2 hours. The mixture was evaporated to dryness and coevaporated with toluene. The resulting white solid (0.2 g) was used in the next step without further purification.

Workup

  1. temperaturerefluxed for 2 hours
  2. customThe mixture was evaporated to dryness
  3. customThe resulting white solid (0.2 g) was used in the next step without further purification

Sources & evidence

ORD record
ord-f8bbb8c4a75541d5942cb7421f31028e
Source dataset
uspto-grants-2015_04
Patent number
US08999998B2

Reaction notes

Loading…