Thionyl Chloride → 3-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride

Participants

Reaction Steps

(1-methyl-1H-1,2,4-triazol-3-yl)methanol (0.25 g, 2.2 mmol) was dissolved in 10 mL of SOCl2 and refluxed for 2 hours. The mixture was evaporated to dryness and coevaporated with toluene. The resulting white solid (0.2 g) was used in the next step without further purification.

Provenance & Evidence