Thionyl Chloride → 5-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride

HRID 1466649Notes

Reaction equation

HRID 1466649 reaction equation
[CH3:1][N:2]1[C:6]([CH2:7]O)=[N:5][CH:4]=[N:3]1.O=S(Cl)[Cl:11]>>[ClH:11].[Cl:11][CH2:7][C:6]1[N:2]([CH3:1])[N:3]=[CH:4][N:5]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 11073377(1-methyl-1H-1,2,4-triazol-5-yl)methanol

Product 1

HCID 222853325-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride

Procedure

(2-methyl-2H-1,2,4-triazol-3-yl)methanol (0.1 g, 0.88 mmol) was dissolved in 10 mL of SOCl2 and refluxed for 2 hours. The mixture was evaporated to dryness and coevaporated with toluene. The resulting white solid (about 0.1 g) was used in the next step without further purification

Workup

  1. temperaturerefluxed for 2 hours
  2. customThe mixture was evaporated to dryness
  3. customThe resulting white solid (about 0.1 g) was used in the next step without further purification

Sources & evidence

ORD record
ord-0d4bbe35b50545ebb5e54fa64707ad84
Source dataset
uspto-grants-2015_04
Patent number
US08999998B2

Reaction notes

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