Thionyl Chloride → 5-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride

Participants

Reaction Steps

(2-methyl-2H-1,2,4-triazol-3-yl)methanol (0.1 g, 0.88 mmol) was dissolved in 10 mL of SOCl2 and refluxed for 2 hours. The mixture was evaporated to dryness and coevaporated with toluene. The resulting white solid (about 0.1 g) was used in the next step without further purification

Provenance & Evidence