反应详情

A solution of 2,2-dimethyl-8-oxododecanoic acid ethyl ester (14.33 g, 5.3 mmol) in Et2O (30 mL) was added to a suspension of LiAlH4 (4.6 g, 12 mmol) in Et2O (200 mL). The reaction mixture was heated to reflux for 2 h. Water (100 mL) and aqueous HCl (10%, 200 mL) were added. The aqueous solution was separated and extracted with Et2O (2×100 mL). The combined organic solutions were washed with saturated, aqueous NaHCO3 solution (100 mL) and brine (50 mL) and dried over MgSO4. The solvent was evaporated and the residue was purified by column chromatography (silica gel, ethyl acetate/hexanes=1:10, 200 mL, then 1:3, 150 mL) to yield 2,2-dimethyldodecan-1,8-diol (9.9 g, 81%) as a colorless oil. 1H NMR (300 MHz, CDCl3/TMS): δ (ppm): 3.55 (br s, 1H), 3.29 (s, 2H), 1.7 (br. s, 2H), 1.42-1.20 (m, 16H), 0.89 (t, J=7.2 Hz, 3H), 0.84 (s, 6H). 13C NMR (75 MHz, CDCl3/TMS): δ (ppm): 72.1, 72.0, 38.7, 37.6, 37.3, 35.2, 30.8, 28.0, 25.8, 24.0, 23.9, 22.9, 14.3. HRMS (LSIMS, gly): Calcd for C14H31O2 (MH+): 231.2324. found: 231.2324. HPLC: 99.8% pure. Elemental analysis (C14H30O2): Calcd for C, 72.99; H, 13.12. Found: C, 72.75; H, 13.23.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 2 h
3. customThe aqueous solution was separated
4. extractionextracted with Et2O (2×100 mL)
5. washThe combined organic solutions were washed with saturated, aqueous NaHCO3 solution (100 mL) and brine (50 mL)
6. dry with materialdried over MgSO4
7. customThe solvent was evaporated
8. customthe residue was purified by column chromatography (silica gel, ethyl acetate/hexanes=1:10, 200 mL