2-Bromoethyl methyl ether → {3-[6-Chloro-1-(2-methoxy-ethyl)-2-methyl-1H-indol-3-ylsulfanyl]-phenyl}-acetic acid

HRID 1466768Notes

Reaction equation

HRID 1466768 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([S:12][C:13]3[CH:14]=[C:15]([CH2:19][C:20]([OH:22])=[O:21])[CH:16]=[CH:17][CH:18]=3)=[C:7]([CH3:11])[NH:8]2)=[CH:4][CH:3]=1.[CH3:23][O:24][CH2:25][CH2:26]Br>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([S:12][C:13]3[CH:14]=[C:15]([CH2:19][C:20]([OH:22])=[O:21])[CH:16]=[CH:17][CH:18]=3)=[C:7]([CH3:11])[N:8]2[CH2:26][CH2:25][O:24][CH3:23])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 66765068[3-(6-Chloro-2-methyl-1H-indol-3-ylsulfanyl)-phenyl]-acetic acid

Product 1

HCID 56840631{3-[6-Chloro-1-(2-methoxy-ethyl)-2-methyl-1H-indol-3-ylsulfanyl]-phenyl}-acetic acid

Procedure

Prepared according to the procedure described in Example 4, Step 1, using the following starting materials: [3-(6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-phenyl]-acetic acid and 2-bromethyl methyl ether.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-528997e3ad8041dbb30f6512e0c32e63
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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