反应详情

温度

80 °C

1(3-Bromo-phenylsulfanyl)-propan-2-one (4.0 g, 16.3 mmol) was dissolved in MeOH:DMF (1:1, 100 mL) and N2 (g) was bubbled through the solution for 5 minutes. Triethylamine (5.7 mL, 40.8 mmol) and (1,1′-bis(diphenylphosphino)ferrocene)-dichloropalladium(II) (0.600 g, 0.82 mmol) were added then CO (g) was bubbled into the reaction mixture for five minutes. The reaction was kept under CO atmosphere and heated to 80° C. overnight. The reaction was worked up then filtered through a plug of silica gel (1:1 EtOAc:hexanes) and concentrated to give the title compound.

1. customN2 (g) was bubbled through the solution for 5 minutes
2. customCO (g) was bubbled into the reaction mixture for five minutes
3. filtrationThe reaction was worked up then filtered through a plug of silica gel (1:1 EtOAc:hexanes)
4. concentrationconcentrated