3-Bromopyridine → 3-(6-Chloro-2-methyl-1-pyridin-3-yl-1H-indol-3-ylsulfanyl)-5-trifluoromethyl-benzoic acid ethyl ester

HRID 1466832Notes

Reaction equation

HRID 1466832 reaction equation
[CH2:1]([O:3][C:4](=[O:27])[C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([S:15][C:16]2[C:24]3[C:19](=[CH:20][C:21]([Cl:25])=[CH:22][CH:23]=3)[NH:18][C:17]=2[CH3:26])[CH:6]=1)[CH3:2].Br[C:29]1[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=1>>[CH2:1]([O:3][C:4](=[O:27])[C:5]1[CH:10]=[C:9]([C:11]([F:13])([F:14])[F:12])[CH:8]=[C:7]([S:15][C:16]2[C:24]3[C:19](=[CH:20][C:21]([Cl:25])=[CH:22][CH:23]=3)[N:18]([C:29]3[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=3)[C:17]=2[CH3:26])[CH:6]=1)[CH3:2]

Participants

3

Reactant 2

HCID 122863-BromopyridineHCID 66765411HCID 66765411, compound

Product 1

HCID 667654073-(6-Chloro-2-methyl-1-pyridin-3-yl-1H-indol-3-ylsulfanyl)-5-trifluoromethyl-benzoic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 42, Step 4, using the following starting materials: 3-(6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-5-trifluoromethyl-benzoic acid ethyl ester and 3-bromopyridine.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-10da934887fd4a9aa7d790340a4c385c
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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