Hydroxyamine hydrochloride → HCID 86686482, compound

HRID 1466886Notes

Reaction equation

HRID 1466886 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([Cl:17])[CH:15]=2)[C:10]([S:18][C:19]2[CH:20]=[C:21]([CH:24]=[CH:25][CH:26]=2)[CH:22]=O)=[C:9]1[CH3:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:29][OH:30]>N1C=CC=CC=1>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([Cl:17])[CH:15]=2)[C:10]([S:18][C:19]2[CH:20]=[C:21]([CH:24]=[CH:25][CH:26]=2)[CH:22]=[N:29][OH:30])=[C:9]1[CH3:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 86686481HCID 86686481, compound

Product 1

HCID 86686482HCID 86686482, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3-(1-Benzyl-6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-benzaldehyde (0.225 g, 0.57 mmol) was dissolved in pyridine (10 mL) and then hydroxylamine hydrochloride (0.235 g, 3.42 mmol). The reaction stirred at room temperature for 45 minutes and was submitted to an aqueous workup to provide the title compound, which was taken to the next step without further purification.

Sources & evidence

ORD record
ord-9e4df25aecbf469d9318ad8ef46fcef3
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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