Ethanol → Ethyl 6-chloroindole-2-carboxylate
Reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[C:7]([C:11]([OH:13])=[O:12])[NH:8]2)=[CH:4][CH:3]=1.OS(O)(=O)=O.[CH3:19][CH2:20]O>>[CH2:19]([O:12][C:11]([C:7]1[NH:8][C:9]2[C:5]([CH:6]=1)=[CH:4][CH:3]=[C:2]([Cl:1])[CH:10]=2)=[O:13])[CH3:20]Participants
4
Conditions
- Temperature
- 120 °C
Procedure
6-Chloro-1H-indole-2-carboxylic acid (2.59 g, 13.4 mmol) was dissolved in EtOH (75 mL) and conc. H2SO4 (1 mL) was added. The reaction was heated to 120° C. overnight then submitted to aqueous workup to give the title compound.
Sources & evidence
- ORD record
- ord-db477e0effa749ecac46d986b249d986
- Source dataset
- uspto-grants-2015_04
- Patent number
- US09000025B2
Reaction notes
Loading…