4-iodo-1-[(4-methoxyphenyl)methyl]-1H-pyrazole → 3-{6-Chloro-7-fluoro-1-[1-(4-methoxy-benzyl)-1H-pyrazol-4-yl]-2-methyl-1H-indol-3-ylsulfanyl}-benzoic acid ethyl ester

HRID 1466938Notes

Reaction equation

HRID 1466938 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[C:16]([F:22])[C:17]([Cl:21])=[CH:18][CH:19]=3)[NH:14][C:13]=2[CH3:23])[CH:6]=1)[CH3:2].I[C:26]1[CH:27]=[N:28][N:29]([CH2:31][C:32]2[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=2)[CH:30]=1>>[CH2:1]([O:3][C:4](=[O:24])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[C:16]([F:22])[C:17]([Cl:21])=[CH:18][CH:19]=3)[N:14]([C:26]3[CH:27]=[N:28][N:29]([CH2:31][C:32]4[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=4)[CH:30]=3)[C:13]=2[CH3:23])[CH:6]=1)[CH3:2]

Participants

3

Reactant 2

HCID 574219364-iodo-1-[(4-methoxyphenyl)methyl]-1H-pyrazoleHCID 667655043-(6-Chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid ethyl ester

Product 1

HCID 667657853-{6-Chloro-7-fluoro-1-[1-(4-methoxy-benzyl)-1H-pyrazol-4-yl]-2-methyl-1H-indol-3-ylsulfanyl}-benzoic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 55, Step 2 using the following starting materials: 3-(6-chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid ethyl ester and 4-iodo-1-(4-methoxy-benzyl)-1H-pyrazole.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-54237fe10b364c3d911fcba4c224206b
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

Loading…