(3-Chloro-2-fluorophenyl)hydrazine hydrochloride → [3-(6-Chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-2-fluoro-phenyl]-acetic acid ethyl ester

HRID 1466960Notes

Reaction equation

HRID 1466960 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12][CH2:13][C:14](=O)[CH3:15])[C:7]=1[F:17])[CH3:2].Cl.[Cl:20][C:21]1[C:22]([F:29])=[C:23]([NH:27]N)[CH:24]=[CH:25][CH:26]=1>>[CH2:1]([O:3][C:4](=[O:18])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12][C:13]2[C:24]3[C:23](=[C:22]([F:29])[C:21]([Cl:20])=[CH:26][CH:25]=3)[NH:27][C:14]=2[CH3:15])[C:7]=1[F:17])[CH3:2]

Participants

3

Reactant 2

HCID 25067375(3-Chloro-2-fluorophenyl)hydrazine hydrochlorideHCID 66765216[2-Fluoro-3-(2-oxo-propylsulfanyl)-phenyl]-acetic acid ethyl ester

Product 1

HCID 66765437[3-(6-Chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-2-fluoro-phenyl]-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 2, Step 1, using the following starting materials: [2-Fluoro-3-(2-oxo-propylsulfanyl)-phenyl]-acetic acid ethyl ester and (3-chloro-2-fluoro-phenyl) hydrazine hydrochloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e70cdff1dc7c4f9c9b55ec33de5557a2
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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