(3-Chloro-2-fluorophenyl)hydrazine hydrochloride → [5-(6-Chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-2-trifluoromethyl-phenyl]-acetic acid ethyl ester

HRID 1466963Notes

Reaction equation

HRID 1466963 reaction equation
[CH2:1]([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[C:10]([S:12][CH2:13][C:14](=O)[CH3:15])[CH:9]=[CH:8][C:7]=1[C:17]([F:20])([F:19])[F:18])[CH3:2].Cl.[Cl:23][C:24]1[C:25]([F:32])=[C:26]([NH:30]N)[CH:27]=[CH:28][CH:29]=1>>[CH2:1]([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[C:10]([S:12][C:13]2[C:27]3[C:26](=[C:25]([F:32])[C:24]([Cl:23])=[CH:29][CH:28]=3)[NH:30][C:14]=2[CH3:15])[CH:9]=[CH:8][C:7]=1[C:17]([F:20])([F:19])[F:18])[CH3:2]

Participants

3

Reactant 2

HCID 25067375(3-Chloro-2-fluorophenyl)hydrazine hydrochlorideHCID 66764895[5-(2-Oxo-propylsulfanyl)-2-trifluoromethyl-phenyl]-acetic acid ethyl ester

Product 1

HCID 66765688[5-(6-Chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-2-trifluoromethyl-phenyl]-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 2, Step 1, using the following starting materials: [5-(2-Oxo-propylsulfanyl)-2-trifluoromethyl-phenyl]-acetic acid ethyl ester and (3-chloro-2-fluoro-phenyl) hydrazine hydrochloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-54a0f35141d64374ae0615874b7a8fe3
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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