4-iodo-1-propyl-1H-pyrazole → {5-[6-Chloro-7-fluoro-2-methyl-1-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-ylsulfanyl]-2-trifluoromethyl-phenyl}-acetic acid ethyl ester

HRID 1466964Notes

Reaction equation

HRID 1466964 reaction equation
[CH2:1]([O:3][C:4](=[O:29])[CH2:5][C:6]1[CH:11]=[C:10]([S:12][C:13]2[C:21]3[C:16](=[C:17]([F:23])[C:18]([Cl:22])=[CH:19][CH:20]=3)[NH:15][C:14]=2[CH3:24])[CH:9]=[CH:8][C:7]=1[C:25]([F:28])([F:27])[F:26])[CH3:2].I[C:31]1[CH:32]=[N:33][N:34]([CH2:36][CH2:37][CH3:38])[CH:35]=1>>[CH2:1]([O:3][C:4](=[O:29])[CH2:5][C:6]1[CH:11]=[C:10]([S:12][C:13]2[C:21]3[C:16](=[C:17]([F:23])[C:18]([Cl:22])=[CH:19][CH:20]=3)[N:15]([C:31]3[CH:32]=[N:33][N:34]([CH2:36][CH2:37][CH3:38])[CH:35]=3)[C:14]=2[CH3:24])[CH:9]=[CH:8][C:7]=1[C:25]([F:28])([F:26])[F:27])[CH3:2]

Participants

3

Reactant 2

HCID 601366324-iodo-1-propyl-1H-pyrazoleHCID 66765688[5-(6-Chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-2-trifluoromethyl-phenyl]-acetic acid ethyl ester

Product 1

HCID 66765684{5-[6-Chloro-7-fluoro-2-methyl-1-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-ylsulfanyl]-2-trifluoromethyl-phenyl}-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 55, Step 2 using the following starting materials: [5-(6-Chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-2-trifluoromethyl-phenyl]-acetic acid ethyl ester and 4-iodo-1-propyl-1H-pyrazole.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-53baecfa19e24f88916d5fb2cfb780cf
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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