3-Methoxybenzylamine → 3-hydroxy-N-(3-methoxybenzyl)-2,2-dimethylpropanamide

HRID 1467058Notes

Reaction equation

[OH:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4]([OH:6])=O.[CH3:9][O:10][C:11]1[CH:12]=[C:13]([CH2:17][NH2:18])[CH:14]=[CH:15][CH:16]=1>>[OH:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4]([NH:18][CH2:17][C:13]1[CH:14]=[CH:15][CH:16]=[C:11]([O:10][CH3:9])[CH:12]=1)=[O:6]

Participants

Reactant 2

HCID 211563-Methoxybenzylamine

HCID 785483-Hydroxy-2,2-dimethylpropionic acid

Product 1

HCID 667461233-hydroxy-N-(3-methoxybenzyl)-2,2-dimethylpropanamide

Procedure

Prepared as in Example 24a from 3-hydroxy-2,2-dimethylpropanoic acid and (3-methoxyphenyl)methanamine as an orange oil (41%). MS 238 (MH+).

Sources & evidence

ORD record: ord-6ba26b2c0aca4474a0ccf706a8273176
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09000054B2

Reaction notes

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