Ethyl Acetoacetate → HCID 86658209, compound

HRID 1467084Notes

Reaction equation

HRID 1467084 reaction equation
[NH2:1][C:2]1[C:3]([C:25]#[N:26])=[C:4]([CH:22]=[CH:23][CH:24]=1)[O:5][CH2:6][C@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1C(OCC1C=CC=CC=1)=O.O=[C:28]([CH3:35])[CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31]>>[NH2:26][C:25]1[C:3]2[C:2](=[CH:24][CH:23]=[CH:22][C:4]=2[O:5][CH2:6][C@H:7]2[CH2:11][CH2:10][CH2:9][NH:8]2)[N:1]=[C:28]([CH3:35])[C:29]=1[C:30]([O:32][CH2:33][CH3:34])=[O:31]

Participants

3

Reactant 2

HCID 8868Ethyl AcetoacetateHCID 86658210HCID 86658210, compound

Product 1

HCID 86658209HCID 86658209, compound

Procedure

Prepared as in Example 2a from (R)-benzyl 2-((3-amino-2-cyanophenoxy)methyl)pyrrolidine-1-carboxylate (Example 92c) and ethyl 3-oxobutanoate as brown solid. MS 330 (MH+).

Sources & evidence

ORD record
ord-931ef173d29e46299df3cbfd5b394c55
Source dataset
uspto-grants-2015_04
Patent number
US09000054B2

Reaction notes

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