1,4-Benzodioxane-6-carboxylic Acid → (S)-ethyl 4-amino-5-(2-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido) butoxy)-2-methylquinoline-3-carboxylate

HRID 1467099Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1467099
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:12][CH2:13][C@@H:14]([NH2:17])[CH2:15][CH3:16])[N:5]=[C:4]([CH3:18])[C:3]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20].[O:24]1[CH2:29][CH2:28][O:27][C:26]2[CH:30]=[C:31]([C:34](O)=[O:35])[CH:32]=[CH:33][C:25]1=2>>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:12][CH2:13][C@@H:14]([NH:17][C:34]([C:31]2[CH:32]=[CH:33][C:25]3[O:24][CH2:29][CH2:28][O:27][C:26]=3[CH:30]=2)=[O:35])[CH2:15][CH3:16])[N:5]=[C:4]([CH3:18])[C:3]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20]

Komponenten

3

Edukt 2

HCID 27588331,4-Benzodioxane-6-carboxylic AcidHCID 86658218(S)-ethyl 4-amino-5-(2-aminobutoxy)-2-methylquinoline-3-carboxylate

Produkt 1

HCID 86658224(S)-ethyl 4-amino-5-(2-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido) butoxy)-2-methylquinoline-3-carboxylate

Versuchsvorschrift

Prepared as in Example 24a from (S)-ethyl 4-amino-5-(2-aminobutoxy)-2-methylquinoline-3-carboxylate (Example 97b) and 2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid as brown solid (46%). MS 480 (MH+).

Quellen und Nachweise

ORD-Eintrag
ord-b36f43ea17a048349cce02eb75332535
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09000054B2

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